Neuropathic Component in CLBP Patients

Is there a Neuropathic Component to your Patients’ CLBP?1

 Is there a Neuropathic Component to your Patients’ CLBP? 

Potential back conditions that can result in radiculopathy include:2

CLBP: chronic low back pain

References:

  1. Morlion B. Pharmacotherapy of low back pain: targeting nociceptive and neuropathic pain components. Curr Med Res Opin. 2011 Jan;27(1):11-33.
  2. Freynhagen R and Baron R. The evaluation of neuropathic components in low back pain. Curr Pain Headache Rep. 2009 Jun;13(3):185-190.

PP-LYR-SAU-0283

Severity of Chronic Neuropathic Pain is Higher than Other Chronic Pain & Impacts Life

Severity of Chronic Neuropathic Pain is Higher than other Chronic Pain & Impacts Life1

 

BPI = Brief Pain Inventory, which scores the extent to which pain interferes with activities in last 24 hours from 0 (does not interfere) to 10 (completely interferes)

References:

  1. Smith BH et al. Health and quality of life associated with chronic pain of predominantly neuropathic origin in the community. Clin J Pain. 2007; 23(2):143-149.

PP-LYR-SAU-0283

Neuropathic Pain Reduces Employment


Adapted from Meyer-Rosberg K. et al. Eur J Pain. 2001

References:

  1. Meyer-Rosberg K et al. Peripheral neuropathic pain--a multidimensional burden for patients. Eur J Pain. 2001;5(4):379-389.

PP-LYR-SAU-0283

pDPN Affects "Patients" daily Activities

Painful DPN is associated with decrements in many aspects of patientsʹ life1

01. Painful DPN is associated with decrements in many aspects of patientsʹ life 

The goal was to evaluate pain severity, pain-related interference with function, sleep impairment, symptom levels of anxiety and depression, and quality of life among patients with painful diabetic peripheral neuropathy (DPN). Participants in a burden of illness survey (n = 255) completed the modified Brief Pain Inventory-DPN (BPI-DPN), MOS Sleep Scale, Hospital Anxiety and Depression Scale (HADS), Short Form Health Survey-12ν2 (SF-12ν2), and the EuroQoL (EQ-5D). Patients were 61 +/- 12.8 years old (51.4% female), had diabetes for 12 +/- 10.3 years and painful DPN for 6.4 +/- 6.4 years. Average and Worst Pain scores (BPI-DPN, 0-10 scales) were 5.0 +/- 2.5 and 5.6 +/- 2.8. Pain substantially interfered (≥4 on 0-10 scales) with walking ability, normal work, sleep, enjoyment of life, mood, and general activity. Moderate to severe symptom levels of anxiety and depression (HADS-A and HADS-D scores≥11 on 0-21 scales) occurred in 35% and 28% of patients, respectively.

MOS: The Medical Outcomes Study

References:

  1. Gore M, Brandenburg NA, Dukes E, et al. Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep. J Pain Symptom Manage. 2005 Oct;30(4):374-385.

PP-LYR-SAU-0283

Pain Reduction Proved Significantly Greater in the Groups treated with LYRICA®1

Lyrica® Significantly reduces neuropathic pain

Lyrica® Significantly reduces neuropathic pain

Efficacy in Acute Pain

Celebrex® Efficacy in Acute Pain treatment

Celebrex® Efficacy in Acute Pain treatment

GI Safety profile

Celebrex® GI Saftey profile

Celebrex® GI Safety profile

Dosing & Administration

Celebrex® Dosing & Administration

Celebrex® Dosing & Administration

Efficacy in Osteoarthritis

Celebrex® Efficacy in Osteoarthritis

Celebrex® Efficacy in Osteoarthritis

Mechanism of Action of Aescin

The mechanism of action of aescin in Reparil Gel

The mechanism of action of aescin in Reparil Gel

Anti-edemetous Activity

Reparil Tablet Anti-edemetous activity

Reparil Tablet Anti-oedematous activity

Treatment Guidelines for DPN

Treatment Guidelines for DPN

Treatment Guidelines for DPN

Treatment Guidelines of Chronic Low Back Pain

Treatment Guidelines of Chronic Low Back Pain

Treatment Guidelines of Chronic Low Back Pain