Pain Osteoarthritis
Neuropathic Component in CLBP Patients
Is there a Neuropathic Component to your Patients’ CLBP?1
Potential back conditions that can result in radiculopathy include:2
CLBP: chronic low back pain
References:
- Morlion B. Pharmacotherapy of low back pain: targeting nociceptive and neuropathic pain components. Curr Med Res Opin. 2011 Jan;27(1):11-33.
- Freynhagen R and Baron R. The evaluation of neuropathic components in low back pain. Curr Pain Headache Rep. 2009 Jun;13(3):185-190.
PP-LYR-SAU-0283
Severity of Chronic Neuropathic Pain is Higher than Other Chronic Pain & Impacts Life
Severity of Chronic Neuropathic Pain is Higher than other Chronic Pain & Impacts Life1
BPI = Brief Pain Inventory, which scores the extent to which pain interferes with activities in last 24 hours from 0 (does not interfere) to 10 (completely interferes)
References:
- Smith BH et al. Health and quality of life associated with chronic pain of predominantly neuropathic origin in the community. Clin J Pain. 2007; 23(2):143-149.
PP-LYR-SAU-0283
Neuropathic Pain Reduces Employment
Adapted from Meyer-Rosberg K. et al. Eur J Pain. 2001
References:
- Meyer-Rosberg K et al. Peripheral neuropathic pain--a multidimensional burden for patients. Eur J Pain. 2001;5(4):379-389.
PP-LYR-SAU-0283
pDPN Affects "Patients" daily Activities
Painful DPN is associated with decrements in many aspects of patientsʹ life1
The goal was to evaluate pain severity, pain-related interference with function, sleep impairment, symptom levels of anxiety and depression, and quality of life among patients with painful diabetic peripheral neuropathy (DPN). Participants in a burden of illness survey (n = 255) completed the modified Brief Pain Inventory-DPN (BPI-DPN), MOS Sleep Scale, Hospital Anxiety and Depression Scale (HADS), Short Form Health Survey-12ν2 (SF-12ν2), and the EuroQoL (EQ-5D). Patients were 61 +/- 12.8 years old (51.4% female), had diabetes for 12 +/- 10.3 years and painful DPN for 6.4 +/- 6.4 years. Average and Worst Pain scores (BPI-DPN, 0-10 scales) were 5.0 +/- 2.5 and 5.6 +/- 2.8. Pain substantially interfered (≥4 on 0-10 scales) with walking ability, normal work, sleep, enjoyment of life, mood, and general activity. Moderate to severe symptom levels of anxiety and depression (HADS-A and HADS-D scores≥11 on 0-21 scales) occurred in 35% and 28% of patients, respectively.
MOS: The Medical Outcomes Study
References:
- Gore M, Brandenburg NA, Dukes E, et al. Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep. J Pain Symptom Manage. 2005 Oct;30(4):374-385.
PP-LYR-SAU-0283
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Pain Reduction Proved Significantly Greater in the Groups treated with LYRICA®1
Lyrica® Significantly reduces neuropathic pain
